Applies UK algorithm on deceased donor's Kidney allocation for transplantation. Ordering of waitlisted candidates for a given donor according to UK transplant algorithm.
Usage
uk(
DRI = "D1",
dA = c("1", "2"),
dB = c("15", "44"),
dDR = c("1", "4"),
dABO = "O",
donor.age = 65,
data = candidates.uk,
D1R1 = 1000,
D1R2 = 700,
D1R3 = 350,
D1R4 = 0,
D2R1 = 700,
D2R2 = 1000,
D2R3 = 500,
D2R4 = 350,
D3R1 = 350,
D3R2 = 500,
D3R3 = 1000,
D3R4 = 700,
D4R1 = 0,
D4R2 = 350,
D4R3 = 700,
D4R4 = 1000,
ptsDial = 1,
a1 = 2300,
a2 = 1500,
b1 = 1200,
b2 = 750,
b3 = 400,
m = 40,
nn = 4.5,
o = 4.7,
mm1 = -100,
mm23 = -150,
mm46 = -250,
pts = -1000,
df.abs = cabs,
n = 2,
check.validity = TRUE
)Arguments
- DRI
Donor Risk Index group (D1, D2, D3, D4)
- dA
A two elements character vector donor's HLA-A typing.
- dB
A two elements character vector donor's HLA-B typing.
- dDR
A two elements character vector donor's HLA-DR typing.
- dABO
A character value with ABO blood group (O, A, B, AB).
- donor.age
A numeric value with donor's age.
- data
A data frame containing demographics and medical information for a group of waitlisted transplant for UK transplant.
- D1R1
A numeric value (0 - 1000) for the combination of indexes.
- D1R2
A numeric value (0 - 1000) for the combination of indexes.
- D1R3
A numeric value (0 - 1000) for the combination of indexes.
- D1R4
A numeric value (0 - 1000) for the combination of indexes.
- D2R1
A numeric value (0 - 1000) for the combination of indexes.
- D2R2
A numeric value (0 - 1000) for the combination of indexes.
- D2R3
A numeric value (0 - 1000) for the combination of indexes.
- D2R4
A numeric value (0 - 1000) for the combination of indexes.
- D3R1
A numeric value (0 - 1000) for the combination of indexes.
- D3R2
A numeric value (0 - 1000) for the combination of indexes.
- D3R3
A numeric value (0 - 1000) for the combination of indexes.
- D3R4
A numeric value (0 - 1000) for the combination of indexes.
- D4R1
A numeric value (0 - 1000) for the combination of indexes.
- D4R2
A numeric value (0 - 1000) for the combination of indexes.
- D4R3
A numeric value (0 - 1000) for the combination of indexes.
- D4R4
A numeric value (0 - 1000) for the combination of indexes.
- ptsDial
A numeric value for the points corresponding to each month on dialysis.
- a1
A numeric value for HLA match and age combined formula:
b1*cos(age/ 18)+a1- a2
A numeric value for HLA match and age combined formula:
b2*cos(age/ 18)+a2- b1
A numeric value for HLA match and age combined formula:
b1*cos(age/ 18)+a1- b2
A numeric value for HLA match and age combined formula:
b2*cos(age/ 18)+a2- b3
A numeric value for HLA match and age combined formula:
b3*sin(age/ 50)- m
A numeric value for matchability formula:
m* (1 + (MS/nn) ^o)- nn
A numeric value for matchability formula:
m* (1 + (MS/nn) ^o)- o
A numeric value for matchability formula:
m* (1 + (MS/nn) ^o)- mm1
A numeric value to penalize 1 mm.
- mm23
A numeric value to penalize 2-3 mm.
- mm46
A numeric value to penalize 4-6 mm.
- pts
A negative value with penalization for B candidates.
- df.abs
A data frame with candidates' antibodies.
- n
A positive integer to slice the first candidates.
- check.validity
Logical to decide whether to validate input.
Examples
if (FALSE) {
uk(DRI = 'D1', dA = c("1","2"), dB = c("15","44"), dDR = c("1","4"),
dABO = "O", donor.age = 65, data = candidates.uk,
D1R1 = 1000, D1R2 = 700, D1R3 = 350, D1R4 = 0,
D2R1 = 700, D2R2 = 1000, D2R3 = 500, D2R4 = 350,
D3R1 = 350, D3R2 = 500, D3R3 = 1000, D3R4 = 700,
D4R1 = 0, D4R2 = 350, D4R3 = 700, D4R4 = 1000,
ptsDial = 1,
a1 = 2300, a2 = 1500, b1 = 1200, b2 = 750, b3 = 400,
m = 40, nn = 4.5, o = 4.7,
mm1 = -100, mm23 = -150, mm46 = -250,
pts = -1000,
df.abs = cabs, n = 2, check.validity = TRUE)
}