Function reference • histoc

Compatibility

Tests histocompatibility between donor and candidates

abo(): test for ABO compatibility

mmHLA(): number of HLA mismatches

txscore(): TRANSPLANTSCORE (Tx Score)

xmatch(): virtual crossmatch (XM)

cHED(): calculated HLA Evolutionary Divergence (HED) score.

Utilities

Auxiliar functions for allocation algorithms

age_diff(): Donor - recipient age difference

hiper(): Hiperimmunized classification

sp(): Senior Program classification

donor_recipient_pairs(): Candidates' selection according to any algorithm for multiple donors

several(): Runs several time the function donor_recipient_pairs() as bootstrap.

Lima algorithm

Used to compute candidates selection according to Lima’s algorithm

lima(): Lima's algorithm

cp(): Candidates' Color Priority

PT algorithm

Used to compute candidates selection according to Portuguese algorithm

pts(): PT algorithm

pts_HLA(): Points for HLA mismatches

pts_age(): Points for ages' differences

pts_PRA(): Points for cPRA sensitization

ET algorithm

Used to compute candidates selection according to EuroTransplant algorithm

et(): ET algorithm

et_dialysis(): ET points for time on dialysis (in months)

et_mmHLA(): ET points for mmHLA

et_mmp(): Mismatch Probability (MMP) from ETKAS

UK algorithm

Used to compute candidates selection according to United Kingdom algorithm

uk(): UK algorithm

abo_uk(): ABO compatibility on UK's algorithm

b_blood_penalization(): Blood group B match points

ric(): Donor-recipient Risk Index Combination

Equity Matrix algorithm

Used to compute candidates selection according to Equity Matrix algorithm

eqm(): Equity matrix algorithm

uj_matx(): Utility - Justice matrix

Data

data frames availables from the pacakge

candidates: Waiting list with transplant candidates' information.

candidates.uk: Waiting list with UK transplant candidates' information.

donors: Kidney donors' information.

donors.uk: Kidney donors' information from UK transplant.

cabs: Transplant candidates' HLA antibodies.

hlaAet: HLA-A relative frequencies.

hlaApt: HLA-A relative frequencies.

hlaBet: HLA-B relative frequencies.

hlaBpt: HLA-B relative frequencies.

hlaDRet: HLA-DR relative frequencies.

hlaDRpt: HLA-DR relative frequencies.

ABOpt: ABO relative frequencies.

seqs: HLA-A, -B, -C amino-acid sequences in FASTA format.

seqs2: HLA-DRB1, -DQB1 amino-acid sequences in FASTA format.

dst: Grantham distance metric.

package

histoc: histoc: Histocompatibility analysis performed in kidney allocation systems for transplantation.